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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Crocin, Fluorouracil
Phytochemical Name Crocin (PubChem CID: 5281233 )
Anticancer drug Name Fluorouracil (PubChem CID: 3385 )
Structure of
Phytochemical		 2D-img
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Decreasing Drug Toxicity
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The theory of cold and heat
Drug Name Fluorouracil
Adverse Reactions Application site erythema, application site pruritus. This was inferred hot nature anticancer drug.
Recommendations Cold: Pueraria thomsonii; Bupleurum scorzonerifolium; Pueraria thomsonii; Pueraria edulis
Reference Traditional Chinese medicine characteristics of chemotherapy regimens in advanced gastrointestinal malignant tumours[J]. Global Traditional Chinese Medicine,2023,16(8):1596-1599. DOI:10.3969/j.issn.1674-1749.2023.08.019.　　ref_link
Combination Pair ID: 714
Ref_1
Pair Name Crocin, Fluorouracil
Disease Info [ICD-11: 2B91] Colorectal cancer Investigative
Gene Regulation Down-regulation Phosphorylation AKT1 hsa207
Down-regulation Expression CCND1 hsa595
Up-regulation Expression CDH1 hsa999
Down-regulation Expression PIK3CB KEGG ID N.A.
In Vitro Model CT26 Mouse colon adenocarcinoma Mus musculus (Mouse) CVCL_7254
In Vivo Model Eight-week old female C57BL/6 mice were supplied by Pasteur Institute (Tehran, Iran) and divided into four groups (n = 6 each): control, treated with 5-FU, or crocin, or a 5-FU/crocin combination. Mice were given a single intraperitoneal injection of AOM (10 mg/kg body weight followed by three cycles of 1.5% DSS in drinking water for 1 week and normal drinking water for 2 weeks.
Result We demonstrated an antitumor activity of crocin in CRC and its potential role in improvement of inflammation with mucosal ulcers and high-grade dysplastic crypts, supporting the desireability of further investigations on the therapeutic potential of this approach in CRC.
03. Reference
No. Title Href
1 Crocin synergistically enhances the antiproliferative activity of 5-flurouracil through Wnt/PI3K pathway in a mouse model of colitis-associated colorectal cancer. J Cell Biochem. 2018 Dec;119(12):10250-10261. doi: 10.1002/jcb.27367. Click
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